Pharmacokinetics and biodistribution of supraparticle-delivered neurotrophin 3 in the guinea pig cochlea

N Gunewardene; P Lam; Y Ma; F Caruso; S Wagstaff; RT Richardson; AK Wise

Journal article

Pharmacokinetics and biodistribution of supraparticle-delivered neurotrophin 3 in the guinea pig cochlea

N Gunewardene, P Lam, Y Ma, F Caruso, S Wagstaff, RT Richardson, AK Wise

Journal of Controlled Release | ELSEVIER | Published : 2022

DOI: 10.1016/j.jconrel.2021.12.037

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Abstract

Hearing loss is the most prevalent sensory disorder affecting nearly half a billion people worldwide. Aside from devices to assist hearing, such as hearing aids and cochlear implants, a drug treatment for hearing loss has yet to be developed. The neurotrophin family of growth factors has long been established as a potential therapy, however delivery of these factors into the inner ear at therapeutic levels over a sustained period of time has remained a challenge restricting clinical translation. We previously demonstrated that direct delivery of exogenous neurotrophin-3 (NT3) in the guinea pig cochleae via a bolus injection was rapidly cleared from the inner ear, with almost complete elimina..

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University of Melbourne Researchers

Frank Caruso Author

Rachael Richardson Author

Andrew Wise Author

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Funding Acknowledgements

This work was funded with support from the Department of Defense USA, Hearing Restoration Research Program, Translational Research Award W81XWH1810276, The Garnett Passe and Rodney Williams Memorial Foundation, the Australian National Health and Medical Research Council (GNT 1142910, GNT2000202), and the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). The Bionics Institute acknowledges the support it receives from the Victorian Government, Australia, through its Operational Infrastructure Support Program. The authors would like to thank Trung Nguyen, Donna Tuari, James Firth, Sayward Barone, Brianna Flynn, Alex Thompson, Ella Trang and Caitlin Singleton from the Bionics Institute, Melbourne, Australia, for technical assistance, Patricia WM Ho from St Vincent's Institute, Melbourne, Australia for the use of the gamma counter and David Casley from ProSearch International, Melbourne, Australia, for technical assistance with protein radiolabelling.